结直肠癌中的内微生物群:专注于特定的分布和潜在的机制
Jing Long1, Jiamei Wang1, Chong Xiao1,2
1TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610036, China.
Cell communication and signaling : CCS
|September 26, 2024
概括
结肠直肠癌 (CRC) 内微生物群通过改变瘤微环境和宿主细胞来影响瘤的进展. 了解这些微生物相互作用是开发新型微生物相关治疗策略的关键.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症相关死亡的主要原因.
- 下一代测序揭示了CRC中内微生物群的存在和重要性.
- 这些微生物在CRC发展和进展中的作用是一个新兴的研究领域.
研究的目的:
- 审查了解CRC内微生物群的当前进展.
- 讨论这些微生物对CRC进展的影响,包括基于瘤特征的差异.
- 探索内微生物群影响CRC.的机制.
主要方法:
- 文献综述综合了关于CRC内微生物群的当前研究.
- 分析研究的微生物组成和丰富性与瘤位置,分子亚型,阶段和空间分布有关的研究.
- 检查将内微生物群与CRC发展联系起来的机制性途径.
主要成果:
- 内微生物群通过调节结肠上皮细胞,瘤细胞和瘤微环境,显著影响CRC.
- 机制包括诱导DNA损伤,亡和上皮细胞-介质细胞过渡.
- 微生物对CRC的影响可能是二分化的,观察到有益和有害的作用.
结论:
- 在不同CRC亚型和位置之间存在内微生物群组成的差异.
- 需要使用综合性协议和体外模型进行进一步的研究,以阐明CRC中的微生物机制.
- 了解这些机制将有助于临床应用与微生物相关的治疗CRC和潜在的其他癌症.
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