神经病理学新鲜事2024年:中枢神经系统WHO第五版更新
Heather Smith1, Jared T Ahrendsen1
1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Journal of pathology and translational medicine
|September 27, 2024
概括
2021年世界卫生组织 (WHO) 中枢神经系统 (CNS) 瘤分类整合了先进的分子测试,用于精确的瘤分类和识别. 这次更新强调了分子特征,以改善中枢神经系统瘤分类.
科学领域:
- 神经病理学神经病理学
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 世界卫生组织 (WHO) 发布了2021年中枢神经系统瘤分类的第五版.
- 这个版本仅在第四版之后五年,反映了快速的进步.
- 分子检测已经成为准确的瘤诊断和分类的关键.
研究的目的:
- 概述2021年世卫组织中枢神经系统瘤分类中的重大更新.
- 要突出在中枢神经系统瘤诊断中对分子分析的重视.
- 为了简要概述修订后的分类系统.
主要方法:
- 审查2021年世卫组织中枢神经系统瘤分类指南.
- 分析关键的分子测试方式,包括下一代测序,RNA融合分析和DNA甲基化分析.
- 综合有关新发现的瘤类型和修订的分类信息.
主要成果:
- 2021年的分类包括先进的分子数据,以更精确地分类瘤.
- 基于分子特征,新的中枢神经系统瘤实体已经被识别出来.
- 由于分子洞察力,现有的瘤类型现在可以更准确地被分类.
结论:
- 2021年世卫组织中枢神经系统瘤分类标志着向基于分子的诊断转向范式的转变.
- 增强的分子表征对于准确的中枢神经系统瘤分类和患者管理至关重要.
- 这一更新的分类为了解和诊断中枢神经系统瘤提供了一个精细的框架.
相关概念视频
Diagnostic and Statistical Manual of Mental Disorders (DSM)
48
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
48
Neural Regulation
39.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.2K
Neurogenesis and Regeneration of Nervous Tissue
739
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
739
Neuron Structure
12.7K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
12.7K


