在IgA脏病中准B细胞的向
1Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Nephrology (Carlton, Vic.)
|September 27, 2024
概括
IgA脏病 (IgAN) 源于银河糖缺乏IgA1 (GdIgA1) 并且涉及补体激活. 新的疗法针对GdIgA1产生B细胞和通路,为IgAN治疗提供希望.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- IgA脏病 (IgAN) 与"多重命中理论"有关,起源于银河糖缺乏IgA1 (GdIgA1).
- 慢性补充通路激活 (替代和乳清) 驱动淋巴细胞损伤,导致蛋白尿和纤维化.
- 目前正在积极研究GdIgA1的产生机制和向疗法.
研究的目的:
- 审查负责GdIgA1生产中的B细胞的作用.
- 阐明GdIgA1合成背后的分子机制.
- 提供针对GdIgA1生产的正在进行的治疗策略的概述.
主要方法:
- 对IgAN病变发生的临床和基础研究结果的审查.
- 涉及托尔类受体 (TLR),APRIL和BAFF的分子机制的分析.
- 针对新型IgAN疗法的正在进行的国际临床试验的摘要.
主要成果:
- 原性GdIgA1很可能是粘膜来源的聚合IgA1,由差异化B细胞产生.
- 粘膜先天免疫,包括TLRs (TLT9,TLR7) 和细胞因子APRIL/BAFF,都与GdIgA1的产生有关.
- 临床试验正在评估TLR调节剂,抗APRIL/BAFF剂和细胞减小药物.
结论:
- 了解B细胞的GdIgA1生产对于IgAN治疗至关重要.
- 针对GdIgA1的生产,代表了对IgAN的有前途的治疗途径.
- 目前正在进行的研究和临床试验正在推动IGAN管理.
相关概念视频
01:15Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
01:17Gastritis-II: Pathophysiology
273
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
273
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
119
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
119
01:24B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K