相关实验视频

Updated: Jun 12, 2025

Murine Ileocolic Bowel Resection with Primary Anastomosis

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

益生菌对改善肠粘膜透性和手术后炎症的影响

Min-Jae Kim¹, Young Ju Lee¹, Zahid Hussain¹

¹Division of Gastroenterology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

|September 27, 2024

概括

益生菌预治疗可以通过减少肠道炎症和透性来改善术后阴茎 (POI). 这项研究研究了在几内亚猪模型中的机制,包括紧结蛋白表达.

科学领域:

胃肠病学胃肠病学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

手术后的腹膜 (POI) 是腹部手术后的一个常见并发症.
了解POI的机制对于开发有效的治疗方法至关重要.

研究的目的:

调查益生菌预处理改善术后阴茎 (POI) 的机制.
在POI模型中评估益生菌对肠道透性,炎症,紧结蛋白表达和IL-17水平的影响.

主要方法:

建立了一个POI的试验小猪模型.
动物被分为控制,POI和益生菌组.
测量了肠道透性,炎症标志物 (白细胞计数,calprotectin),紧结蛋白 (occludin,ZO-1),以及血IL-17.

主要成果:

在POI模型中,益生菌预处理显著降低了肠道透性和炎症.
益生菌恢复了紧接口蛋白质occludin和zonula occludens-1的表达.
肌肉层中的益生菌降低了calprotectin的表达,但IL-17水平没有显著差异.

结论:

益生菌预处理为管理POI提供了潜在的治疗策略.
这些好处很可能是通过肠道透性降低,炎症和改善紧密结合完整性的介导.

关键词:

伊利乌斯 (Ileus) 是一个小岛.介质蛋白-17 介质蛋白-17 介质蛋白肠道的透性肠道的透性益生菌益生菌是一种益生菌.紧密结合蛋白质是紧密结合的蛋白质.

更多相关视频

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran

Published on: November 18, 2022

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery

Published on: October 4, 2024

相关概念视频

Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease

Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents

The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...