患有急性淋巴细胞白血病的儿童的生存率与基于风险组的协议变化:在20年的时间内与460名患者的单中心经验
Na Hee Lee1, Hee Young Ju2, Eun Sang Yi3
1Department of Pediatrics, Cha Bundang Medical Center, Cha University, Seongnam, Korea.
Cancer research and treatment
|September 27, 2024
概括
儿童急性淋巴细胞白血病 (ALL) 的生存率显著改善. 对青少年患者和复发性疾病患者需要进一步的研究.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 临床研究 临床研究
背景情况:
- 风险分层对于现代儿科急性淋巴细胞白血病 (ALL) 治疗至关重要.
- 了解长期生存和预后因素对于改善患者的治疗结果至关重要.
研究的目的:
- 在20年的时间内评估儿科ALL患者的生存率和确定预后因素.
- 评估不断变化的治疗方案对患者治疗结果的影响.
主要方法:
- 在三星医疗中心 (SMC) 治疗的460名儿科ALL患者的分析.
- 患者被分为标准风险 (SR),高风险 (HR) 和非常高风险 (VHR) 组.
- 在研究期间 (2000-2019年) 更新了HR组治疗方案.
主要成果:
- 整体10年生存率 (OS) 为83.8%.
- 根据风险组的生存率有所不同:SR (95.9%),HR (83.8%),VHR (66.2%).
- 在HR组中观察到改善的OS与更新的协议,特别是1501协议 (96.2%的5年OS).
结论:
- 儿科ALL的治疗结果明显改善.
- 需要对青少年/年轻成年患者和复发疾病患者进行进一步的表征.
- 持续完善风险分层治疗方案至关重要.
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