相关实验视频

Updated: Jun 12, 2025

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

蜂蜜和草溶液增加了生存率,并调节了瘤大小在vivo中

Rebeka Tomasin¹, Ianca Carneiro Ferreira¹, Alexandra Christine Helena Frankland Sawaya²

¹Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, 13083-970, Brazil.

Molecular nutrition & food research

|September 27, 2024

概括

蜂蜜和草 (HA) 溶液及其乙醇提取物显示抗癌活性. 乙醇提取物对癌细胞产生更大的细胞毒性作用,并改善了体内生存率,这表明它有可能作为辅助性癌症治疗.

科学领域:

综合性瘤学是一种综合性瘤学.
自然产品化学自然产品化学
癌症生物学癌症生物学

背景情况:

蜂蜜和 (Aloe vera) 具有营养成分,导致它们被用作补充癌症治疗.
研究这些天然化合物的特定抗癌机制和疗效对于治疗开发至关重要.

研究的目的:

评估蜂蜜和A. vera溶液的体外和体内抗癌活性.
为了比较标准溶液及其乙醇提取的效果.

主要方法:

使用UPLC-ESI-MS/MS进行蜂蜜和A. vera (HA) 溶液及其乙醇提取 (E) 样品的比较分析.
在实验室中评估了对MCF-7和Walker-256癌细胞系的细胞毒性和抗增殖作用.
在沃克-256瘤携带的老鼠体内评估疗效,监测存活率和NK细胞透.

主要成果:

只有在最高剂量时,HA溶液才对沃克瘤细胞活力产生影响.
乙醇提取物 (E) 对MCF-7和Walker-256细胞表现出更显著的细胞毒性和抗增殖作用.
在体内研究表明,与治疗乙醇提取物 (WE组) 的沃克-256瘤携带大鼠的生存率增加,与HA治疗组 (WHA) 相比,NK细胞透到瘤组织的增强.

结论:

该研究提供了蜂蜜和A. vera溶液对瘤细胞的选择性细胞毒性的证据,归因于它们的生物活性化合物.
蜂蜜和A. vera的乙醇提取物显示出有希望的细胞毒性和抗增殖性质.
这些发现支持蜂蜜和A. vera溶液作为辅助癌症治疗的基础的潜在使用.

关键词:

细胞毒性影响细胞毒性影响在体内有免疫刺激作用.含有多糖的多糖化合物的内容.瘤的生长瘤的生长

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles

Published on: June 28, 2021

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...