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神经炎症与治疗目标在外科手术后神经认知障碍中的相关性
Fahad Khan1, Meenakshi Verma2, Indra Rautela3
1Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India.
Current pharmaceutical biotechnology
|September 27, 2024
概括
老年人的外科神经认知障碍 (PND) 与神经炎症有关. 本综述探讨了PND机制和治疗点,包括各种受体,以改善患者的治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 老年医学 老年医学
- 麻醉学 麻醉学
背景情况:
- 在外科手术和麻醉后的老年患者中,外科神经认知 (PND) 障碍很常见.
- 神经炎症是PND发展的关键可疑因素,特别是在老年人中.
研究的目的:
- 为提供神经炎症在PND中的作用的全面概述.
- 确定潜在的治疗目标和生物标志物用于PND管理.
- 审查与术后神经认知障碍相关的当前临床试验.
主要方法:
- 文献综述专注于PND中的神经炎症.
- 分析各种受体 (PRRs,化学因子,免疫球蛋白超级家族, purinergic) 在PND病变发生过程中的参与.
- 术后神经认知障碍的临床试验摘要.
主要成果:
- 神经炎症是PND的一个重要因素.
- 几种受体类型涉及到PND的发展,可以作为生物标志物.
- 临床试验为当前的治疗策略提供了洞察力.
结论:
- 了解神经炎症对于老年患者的PND管理至关重要.
- 针对特定的受体提供了一个有希望的治疗途径.
- 需要进一步的研究和临床试验来开发有效的PND治疗方法.
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