相关实验视频
Updated: Jun 12, 2025

10:10
Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
12.7K
癌症患者的情绪,焦虑和认知变化
Gabriela Noronha Fortes1, Marcos Fraga Fortes1, Marcos Noronha Fortes2
1Universidade de São Paulo, São Paulo, Brazil.
Journal of surgical oncology
|September 27, 2024
概括
癌症 (CC) 与炎症,认知缺陷和情绪障碍有关. 癌症患者中MCP-1细胞因子水平升高与语言能力保持相关,但需要进一步研究来理解这些复杂的关系.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 癌症 (CC) 是一个复杂的多因素综合征.
- CC与显著的体重减轻,炎症和代谢变化有关.
- CC对情绪,焦虑和认知功能的影响仍然是积极研究的领域.
研究的目的:
- 为了研究癌症缓解症患者脑脊液 (CSF) 中的细胞因子 (cytokine) 概况.
- 评估CC患者的情绪,焦虑和认知特征.
- 探索细胞因子水平,临床参数和CC中的神经心理缺陷之间的相关性.
主要方法:
- 评估了109个人的队列,包括对照组,没有缓冲症 (CWC) 的癌症患者和癌症缓冲症 (CC) 患者.
- 神经心理学评估包括情绪 (BDI),焦虑 (HADS) 和认知 (Digit Span,WASI子测试) 的测试.
- 对脑脊液 (CSF) 进行了细胞因子 (MCP-1,VEGF,IL-8,IP-10,MIP-1β) 分析,并使用QLQ-C30问卷评估了生活质量.
主要成果:
- 康复组的抑郁症 (62.96%) 和焦虑/抑郁症 (62.96%) 率较高,其中75.92%的人表现出注意力缺陷.
- 与对照组相比,WASI-词汇测试的CC和CWC组观察到显著的认知障碍.
- 与对照组相比,CC患者报告生活质量降低,体重减轻和BMI降低. 在CC患者的CSF中检测到MCP-1升高和MIP-1β和VEGF降低.
结论:
- 在CC中精神障碍与炎症,体重减轻,低BMI和生活质量下降有关.
- CC组呈现出更高的抑郁/焦虑和认知缺陷的患病率,抑郁和炎症之间的联系更强.
- 与精神障碍相关的低CSF细胞因子和CC中系统CRP升高的悖论需要进一步调查. 升高的MCP-1与保留的语言能力相关.
相关概念视频
Psychoneuroimmunology: Diabetes and Cancer
25
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
25
Cancer Survival Analysis
331
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
331
Altered States of Awareness
157
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
157
Stress and Mental Health
84
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
84
Psychological Responses to Stress
47
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
47
Anxiety: Overview
255
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
255

