在COVID-19感染后使用二维剪切波弹性图形对肝脏的评估:试点研究
Joyce Yea See Lau1,2, Sandra O'Hara1, Paul Lombardo2
1SKG Radiology Level 3, 1 Hood Street Subiaco 6008 Western Australia Australia.
Australasian journal of ultrasound in medicine
|September 27, 2024
概括
在轻度病例中,COVID-19感染可能会增加肝硬度,测量值明显高于未感染个体. 自感染以来的时间并没有显著改变肝硬度的短期变化.
科学领域:
- 肝病学和病毒性传染病
- 医学成像和诊断 医学成像和诊断
背景情况:
- 冠状病毒疾病 (COVID-19) 可以影响包括肝脏在内的多个器官,据报道肝酶水平升高.
- COVID-19感染对肝硬度 (衡量肝脏健康的指标) 的影响仍然不确定.
研究的目的:
- 为了确定轻度的COVID-19感染是否与未感染个体相比显著改变肝硬度.
- 为了调查自COVID-19感染以来的时间是否影响肝硬度.
主要方法:
- 展望性研究涉及68名参与者,分为COVID-19组 (n=34) 和对照组 (n=34).
- 用于测量肝硬度的二维切割波弹性图 (2D-SWE).
- 统计分析包括独立的t测试和单向ANOVA,以根据感染后的时间 (<2个月,2-4个月,4-6个月) 来比较组和子组.
主要成果:
- 与对照组 (4.30 ± 0.96 kPa) 相比,COVID-19组的平均肝硬度 (5.26 ± 1.63 kPa) 显着更高 (P=0.005).
- 根据感染后的时间 (P=0.143) 在COVID-19亚组中没有发现肝硬度的显著差异.
结论:
- 与对照人群相比,在COVID-19感染后的个体中观察到肝硬度的统计显著增加.
- 这些发现表明COVID-19对肝硬度的潜在短期影响,尽管临床意义和长期影响需要进一步调查.
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