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慢性腹腔内血瘤的药理景观:随机和非随机对照研究的系统审查和网络元分析

Tao Liu¹, Zhihao Zhao¹, Mingqi Liu¹

¹Department of Neurosurgery, Tianjin Neurological Institute, State Key Laboratory of Experimental Hematology, Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous System Tianjin & Ministry of Education , Tianjin Medical University General Hospital, 154 Anshan Road, Tianjin 300052, China.

|September 27, 2024

概括

与葡萄糖皮质类药物结合的他类药物通过减少复发和改善治疗结果,对治疗慢性下皮质血瘤 (CSDH) 有希望. 单独使用他类药物可能是降低死亡率和预防CSDH患者不良事件的最佳方法.

科学领域:

神经外科神经外科
药理学药理学是指药理学的学科.
基于证据的医学基于证据的医学

背景情况:

慢性亚皮血瘤 (CSH) 提供了多种治疗选择,关于药物干预的争论正在进行中.
关于各种CSH治疗方式的比较疗效和安全性存在缺乏共识.

研究的目的:

为了研究药物干预的疗效和安全性,慢性腹腔内血瘤.
为CSH药理管理提供潜在的临床建议.

主要方法:

在PubMed,Web of Science,Embase和Cochrane图书馆 (2000-2023) 的系统搜索中,确定了相关的随机和非随机受控研究.
网络元分析被用来汇集复发,预后,不良事件,血瘤体积减少和死亡率的估计.
对网络元分析判断 (CI) 的信心被用来评估证据质量.

主要成果:

类药物加上葡萄糖皮质类药物 (GCs) 在预防复发,改善预后和促进血液瘤吸收方面表现出最高的疗效.
特兰胺酸在预防复发方面显示出第二高的疗效.
类药物成为降低死亡率和预防不良事件的首选药物,而抗血栓剂表现不佳.

结论:

与GC结合的他类药物可能是对CSH最有效的治疗方法,增强恢复和吸收.
单独使用他类药物在降低死亡率和预防CSH患者的不良事件方面显得更好.
不建议进行常规的GC;需要进一步的研究来验证这些发现并直接比较干预措施.

关键词:

慢性腹膜下血腫慢性腹膜下血腫葡萄糖皮质类药物是什么进行元分析分析.药理干预措施药理干预措施随机对照研究随机对照研究复发情况复发情况类他类药物是一种药物.

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