肠道微生物群与癌症治疗的相互作用
1From The University of Texas MD Anderson Cancer Center, Houston, Texas.
Journal of the advanced practitioner in oncology
|September 27, 2024
概括
肠道微生物群影响癌症的发展和治疗反应. 本综述探讨了它在各种癌症中的作用以及在接受化疗或免疫治疗的患者中修改肠道微生物群的当前策略.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物组显著影响宿主健康,影响新陈代谢,情绪和认知.
- 新兴研究强调了肠道微生物在癌症病原和治疗疗效中的关键作用.
- 了解这些相互作用对于推进癌症治疗至关重要.
研究的目的:
- 审查肠道微生物群对特定癌症发病的影响.
- 讨论目前用于修改接受化疗或免疫治疗的癌症患者肠道微生物组的指导方针.
- 确定微生物物种与癌症疗法之间的关系.
主要方法:
- 文献综述专注于肠道微生物组在癌症中的作用.
- 对特定癌症的研究分析:结肠直肠癌,黑色素瘤,细胞癌,非小细胞肺癌,淋巴瘤和急性白血病.
- 检查治疗方法,特别是检查点抑制剂,以及它们与肠道微生物群的相互作用.
主要成果:
- 肠道微生物组影响癌症的发展和患者对化疗和免疫疗法等治疗的反应.
- 在某些用与肠道微生物群相互作用的疗法治疗的癌症中观察到显著的生存改善.
- 将微生物种与治疗结果联系在一起的精确机制在很大程度上仍未被定义.
结论:
- 肠道微生物组是癌症发病和治疗的关键因素.
- 需要进一步的研究来澄清肠道微生物与癌症疗法之间的复杂相互作用.
- 调节肠道微生物组有可能改善癌症患者的治疗结果.
相关概念视频
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
What is Monogastric Digestion?
70.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
70.9K
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Inflammatory Bowel Disease IV: Pharmacological Management
118
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
118


