患有自闭症谱系障碍的儿童和健康的兄弟姐妹的肠道微生物群:一项比较研究
Dalia Abuljadayel1, Asalah Alotibi1, Khloud Algothmi1,2
1Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Experimental and therapeutic medicine
|September 27, 2024
概括
自闭症谱系障碍 (ASD) 与肠道微生物组合的改变有关. 与健康的兄弟姐妹相比,患有自闭症的孩子表现出更高水平的某些细菌,包括致病性属,并增加了微生物多样性.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
背景情况:
- 自闭症谱系障碍 (ASD) 是一种影响社会沟通的神经发育状况.
- 人类肠道微生物组 (GM) 在本地肠道过程和病原体防御中发挥作用.
- 肠道微生物组失调越来越被认为是ASD的潜在因素.
研究的目的:
- 在肠道微生物群中对ASD分子生物标志物进行分类和识别.
- 为了比较ASD儿童和他们的健康兄弟姐妹之间的肠道微生物组成.
主要方法:
- 来自四名患有自闭症儿童和四名健康兄弟姐妹 (3-10岁) 的便样本的全基因组猎枪测序.
- 生物信息分析用于对肠道微生物群的基因,分类学和丰度概况进行目录.
- 确定前10个最丰富的基因及其在每个组中的功能对应物.
主要成果:
- 总共有673,091个基因被目录,代表了25个类,2个王国,257个家族,34个类,84个顺序和1314个属.
- 患有自闭症的儿童表现出更高的特定肠道微生物群的丰富性,包括Firmicutes和Proteobacteria类和Lactobacillaceae家族.
- 自闭症组显示,Bacteroides属的丰富性增加,Bifidobacterium和Prevotella属的丰富性减少,整体生物量,多样性和丰富性更高.
结论:
- 患有自闭症儿童和他们的健康兄弟姐妹之间存在肠道微生物组合的显著差异.
- 特定的细菌属和物种,以及整体的微生物生物量和多样性,可以作为ASD的潜在生物标志物.
- 这些发现表明肠道失调和ASD病理生理学之间存在联系.
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