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Updated: Jun 12, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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通过小分子降解剂对特定TEAD类型的有针对性的降解

Hui Chen1, Artem Gridnev2,3, Netanya Schlamowitz2,4

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.

Heliyon
|September 27, 2024
PubMed
概括

新型的PROTAC分子HC278特别准并降解TEAD1和TEAD3,这些关键蛋白质与癌症有关. 这一发现为研究TEAD功能和开发TEAD驱动疾病治疗方法提供了一个新的化学工具.

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