长期COVID的草药:第二阶段试点临床研究
Tae-Hun Kim1, Jiwon Yoon2, Sanghyun Kim3
1Korean Medicine Clinical Trial Center, Korean Medicine Hospital, Kyung Hee University, Seoul, Republic of Korea.
Heliyon
|September 27, 2024
概括
东亚传统的草药药物对长期的COVID疲劳有希望. 这项试点研究发现Bojungikgi-tang,Kyungok-go和Cheonwangbosim-dan在缓解长期COVID患者疲劳方面是可行的和有效的.
科学领域:
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
背景情况:
- 冠状病毒疾病-2019 (COVID-19) 感染可能导致持续的症状,称为长期COVID.
- 长期的COVID与显著的疲劳和认知功能障碍有关,影响患者的生活质量.
- 需要有效治疗长期COVID症状,包括探索传统医学.
研究的目的:
- 评估对长期COVID的草药临床研究的可行性.
- 评估三种东亚草药在治疗长期COVID相关疲劳和认知功能障碍方面的疗效和安全性.
- 用特定的草药配方来确定疲劳和认知症状的治疗成功率.
主要方法:
- 一项涉及45名长期COVID患者的前性试点研究.
- 在12周内使用三种草药Bojungikgi-tang (BIT),Kyungok-go (KOG) 和Cheonwangbosim-dan (CBD).
- 评估36周的疲劳和认知功能结果,并监测药物坚持和不良事件.
主要成果:
- 在12周后,所有治疗组的疲劳症状显著改善.
- 对于疲劳的治疗成功率为80% (BIT),53.33% (KOG) 和46.67% (CBD).
- 认知功能障碍的改善率不同:40% (BIT),46.67% (KOG) 和13.33% (CBD);所有不良事件都是轻微的,与治疗无关.
结论:
- 在长期COVID中使用草药的临床试验设计是可行的.
- 观察到很高的药物坚持,支持这种治疗方法的实用性.
- 传统的东亚草药显示出缓解长期COVID的关键症状的潜力,特别是疲劳.
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