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差异化甲状腺癌和不良妊娠结果:一个倾向性得分匹配的回顾性队列研究
Xin Li1, Fang Mei2, Wu-Cai Xiao3
1Department of General Surgery, Peking University Third Hospital, Beijing, China.
Frontiers in pediatrics
|September 27, 2024
概括
分化甲状腺癌 (DTC) 治疗没有增加女性不良妊娠结果. 然而,在怀孕期间对DTC的积极监测需要进一步研究,因为早产和产前的风险增加.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 分化甲状腺癌 (DTC) 越来越多地被诊断为生育年龄的女性.
- 关于DTC对妊娠结果的影响现有证据是不一致的.
- 这项研究调查了先前诊断的妇女的DTC和不良妊娠结果.
研究的目的:
- 评估差异化甲状腺癌 (DTC) 与不良妊娠结果之间的关联.
- 为了比较DTC治疗的女性与接受主动监测的女性的结果.
- 为有DTC史的孕妇提供个性化的产前护理信息.
主要方法:
- 北京大学第三医院的回顾性队列研究 (2012-2022年).
- 包括单独怀孕和怀孕前的DTC (手术后或监视下).
- 倾向分数匹配用于将DTC组与非DTC组进行比较.
主要成果:
- 在倾向性得分匹配后,接受DTC治疗的女性没有增加不良妊娠结果的风险.
- 接受DTC积极监测的妇女患早产,孕前和低出生体重婴儿的风险更高.
- 基于甲状腺功能障碍或孕期甲状腺激素水平的亚组之间没有发现显著差异.
结论:
- 分化甲状腺癌 (DTC) 治疗与不良妊娠结果无关.
- 由于风险增加,在积极监视下DTC的孕妇需要更密切的监测.
- 需要进一步的研究来澄清与怀孕期间主动监测相关的风险.
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