新生儿高剂量雷米芬坦尼尔麻醉与最小镇静:一个单一中心的回顾性研究
Koshi Suwa1, Kyosuke Takahashi2, Yusuke Iizuka1
1Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, JPN.
Cureus
|September 27, 2024
概括
新生儿高剂量雷米芬坦尼尔麻醉可用于手术,表现出稳定的血液动力学,但需要对呼吸抑制保持警. 为了获得长期的结果,需要进一步的研究.
科学领域:
- 麻醉学 麻醉学
- 新生儿手术 新生儿手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 雷米芬坦尼尔提供快速开始和消除,理论上有助于在麻醉中早期出现.
- 新生儿手术中高剂量雷米芬坦尼尔的使用报告不足,需要对安全性和疗效进行评估.
研究的目的:
- 描述新生儿高剂量雷米芬坦尼尔麻醉技术.
- 评估这种麻醉方法在新生儿外科手术中的安全结果.
主要方法:
- 15例新生儿腹部手术的回顾性观察研究 (2016年1月至2022年2月).
- 高剂量的雷米芬坦尼尔定义为≥0.5mcg/kg/min.
- 收集了有关患者资料,麻醉药物和手术内/术后不良事件的数据.
主要成果:
- 雷米芬坦尼尔的平均输注速率为1.9mcg/kg/min.
- 低血压发生在13%的患者中;没有观察到胸肌梗塞.
- 气管输出平均持续了16分钟;33%的患者接受了纳洛,13%的患者在输出后出现了低氧化症. 在OR后没有发生心肺呼吸系统并发症.
结论:
- 高剂量的雷米芬坦尼尔麻醉可以安全地在新生儿手术中使用,而不会损害血液动力学稳定性.
- 呼吸系统抑郁仍然是一个令人担忧的问题,需要仔细监测和管理.
- 需要长期结果数据才能充分理解这种麻醉策略的影响.
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