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Updated: Jun 12, 2025

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基于结构的CBP/EP300降解器设计:当合作克服亲和力时

Iván Cheng-Sánchez1, Katherine Gosselé1,2, Leonardo Palaferri1

  • 1Department of Chemistry, University of Zurich, Winterthurerstrasse 190, Zurich CH-8057, Switzerland.

JACS Au
|September 27, 2024
PubMed
概括

我们开发了dCE-2,一种新型的PROTAC,可降解CREB结合蛋白 (CBP) 和EP300. 它的有效性取决于合作性,而不仅仅是结合亲和力,使转录调制成为可能.

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When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
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