基于半合成碳水化合物的离子水凝的抗微生物特性和生物相容性
Sina Lambrecht1, Alina Gazizova2, Selin Kara3,4
1Department Life, Light & Matter, University of Rostock Albert-Einstein-Str. 25 18059 Rostock Germany stefan.jopp@uni-rostock.de.
RSC advances
|September 27, 2024
概括
半合成碳水化合物水凝显示抗菌活性对 auris.Candida. 它们的生物相容性取决于启动器系统和像PEGDA这样的交叉连接器,未反应的单体会引起细胞毒性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 聚合物化学 聚合物化学
背景情况:
- 水凝在医学中被广泛使用,天然的多糖水凝被广泛使用.
- 来自可聚合碳水化合物单体的半合成水凝为特定应用提供可调节的特性.
- 基于葡萄糖乙烯基胺酸 (GVIM-I) 的离子水凝还没有得到充分的研究.
研究的目的:
- 描述由GVIM-I.衍生出的半合成碳水化合物基离子基凝.
- 评估这些新型水凝的抗微生物和生物相容性.
- 确定影响水凝细胞毒性的因素,并优化它们用于医疗用途.
主要方法:
- 使用磁盘扩散方法对Candida auris进行评估的抗菌活性.
- 在L929小鼠纤维细胞的细胞活力研究中评估了体外生物相容性.
- 使用LC-MS分析来识别水凝中的液材料.
主要成果:
- 所有GVIM-I水凝样本都显示出对Candida auris生长的抑制作用.
- 水凝酸度与L929纤维细胞活力降低相关.
- 特定的启动器系统和水凝预处理显著影响了细胞活力.
- 聚乙烯甘醇) 二烯酸盐 (PEGDA) 575被确定为一个有前途的交叉连接器.
- 没有反应的GVIM-I被确定为主要的漏细胞毒性成分.
结论:
- 基于GVIM-I的水凝具有抗菌性质和可调节的生物相容性.
- 优化启动器系统,交叉连接器选择 (例如,PEGDA 575) 和预处理对于提高生物相容性至关重要.
- 尽量减少未反应的GVIM-I漏对于这些水凝的安全医疗应用至关重要.
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