饮食中酸盐/酸盐摄入量与肠道微生物代谢物对代谢综合征的相互作用:一个横截面研究
Atieh Mirzababaei1, Maryam Mahmoodi2, Abbasali Keshtkar3
1Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
饮食中酸盐/酸盐来源与肠道微生物代谢物三甲基胺N氧化物 (TMAO) 和金氨酸 (KYN) 相互作用,影响代谢综合征 (MetS) 风险. 动物来源显示有关相互作用,而植物来源表明有保护作用.
科学领域:
- 营养和新陈代谢 营养和新陈代谢
- 肠道微生物组研究研究
- 心血管健康 心血管健康
背景情况:
- 全球代谢综合征 (MetS) 患病率的增加.
- 饮食和肠道微生物代谢物,如TMAO和KYN,都与MetS的发展有关.
- 对饮食与这些代谢产物之间的相互作用的理解有限.
研究的目的:
- 研究饮食中酸盐/酸盐和肠道微生物代谢产物 (TMAO,KYN) 之间的相互作用.
- 检查这些相互作用对MetS及其组件的影响.
主要方法:
- 对250名成年人 (20-50岁) 的横截面研究.
- 通过食物频率问卷 (FFQ) 评估的饮食摄入量.
- 测量了血清TMAO和KYN水平;MetS根据NCEP ATP III标准定义.
主要成果:
- 观察到11%的MetS患病率.
- 积极的相互作用:高动物来源的酸盐/酸盐摄入量与高的TMAO/KYN与高的甘油三,腹部肥胖和较低的HDL相关.
- 动物来源的高酸盐摄入量与高TMAO/KYN的摄入量与高血糖三血症,高血压和较低的HDL风险增加有关.
- 在植物来源的酸盐/亚酸盐和高KYN/TMAO水平之间观察到对MetS组件的负面相互作用.
结论:
- 饮食中酸盐/酸盐的来源 (动物与植物) 与肠道微生物代谢产物 (TMAO,KYN) 相互作用,影响MetS风险.
- 调查结果强调考虑饮食,肠道微生物组,以及它们的相互作用,以评估MetS风险.
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