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非常早产的儿童在生命的第一个十年经历了皮质扩张的改变
Lisa S Gorham1, Aidan R Latham2, Dimitrios Alexopoulos2
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Brain communications
|September 27, 2024
概括
非常早产的婴儿在10岁时表现出追赶大脑的增长,与长期同龄人相比,特定区域的皮质扩张更大. 这种大脑发育会影响认知功能.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 儿科成像学 儿科成像学
背景情况:
- 从怀孕晚期到童年,大脑发育很快,皮层表面积的扩张很大.
- 产后皮质变化的确切机制和位置以及早产的影响仍然不清楚.
研究的目的:
- 为了研究皮质表面积如何从婴儿期发展到非常早产的婴儿和满期婴儿的童年.
- 识别与早产相关的不同扩张模式的特定大脑区域.
主要方法:
- 结构磁共振成像 (MRI) 用于扫描52个非常早产和41个满期婴儿在相当于期限的年龄,并在9/10岁时再次扫描.
- 用解剖学上受约束的多模态表面匹配 (aMSM) 来分析皮层表面重建,以计算局部膨胀梯度.
主要成果:
- 非常早产的婴儿在新生儿时皮质表面积较小,但在9-10岁时与满期同龄人相比,皮质表面积相当.
- 皮层扩张在所有受试者中最明显的是在额叶,叶和顶叶关联皮层.
- 非常早产的儿童在额头部,前部和部区域呈现出更大的扩张,在轨道前部和后部区域具有很高的变化.
结论:
- 过早生育影响早期的大脑发育,但在童年后期发生显著的追赶皮质扩张.
- 关键关联皮层中的差异扩张模式可能与执行功能,情绪和社会认知有关.
- 需要进行进一步的纵向研究,以确定这种扩张是否具有适应性,或者在成年后是否存在差异.
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