维生素D用于慢性阻塞性肺病的管理
Anne Williamson1, Adrian R Martineau1,2, David Jolliffe1
1Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
The Cochrane database of systematic reviews
|September 27, 2024
概括
维生素D补充剂对COPD患者的恶化或肺功能几乎没有影响. 对于维生素D水平非常低或很高的个体,建议进行进一步的研究.
科学领域:
- 肺部医学 肺部医学
- 营养科学 营养科学
- 临床试验 临床试验
背景情况:
- 慢性阻塞性肺病 (COPD) 是全球主要的死亡原因.
- 维生素D缺乏是普遍存在的,并与肺功能减弱和COPD恶化增加有关.
- 目前还没有对维生素D在COPD中的疗效进行全面的元分析.
研究的目的:
- 评估维生素D补充剂对控制COPD恶化和症状的影响.
- 综合来自双盲,随机,安慰剂对照试验的证据.
主要方法:
- 搜索了主要的数据库和试验注册表,查找到2022年8月的相关研究.
- 包括在COPD成年人中对维生素D进行随机,安慰剂控制的试验.
- 主要结局:中度至严重恶化的发生率;次要结局:肺功能 (FEV1),不良事件,死亡率和生活质量.
主要成果:
- 维生素D补充对中度/严重恶化率几乎没有影响 (高确定性证据).
- 没有观察到对肺功能 (FEV1),严重不良事件或死亡率 (中度至低确定性证据) 的显著影响.
- 生活质量和经历恶化症状的参与者比例也没有显著变化.
结论:
- 维生素D补充剂对COPD恶化,肺功能或生活质量几乎没有益处.
- 证据表明,对严重不良事件或死亡率没有重大影响.
- 对具有非常低或非常高维生素D水平的特定人群需要进行进一步的研究.
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