哺乳动物内耳-居民免疫细胞-一个范围审查
Betül Karayay1, Heidi Olze1, Agnieszka J Szczepek1,2
1Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Cells
|September 27, 2024
概括
像巨细胞和淋巴细胞这样的常驻免疫细胞存在于跨物种健康的内耳中. 它们在状中的确切功能尚不清楚,因此需要进一步研究潜在的治疗进展.
科学领域:
- 内耳生物学 内耳生物学
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 研究证实,在健康的内耳中存在住宿性免疫细胞.
- 这种知识是分散在各种物种和研究领域.
研究的目的:
- 系统地审查和整合内部耳朵内存免疫细胞的数据.
- 了解这些细胞在正常生理条件下在不同物种中的存在.
主要方法:
- 对多个数据库 (PubMed,MEDLINE,CINAHL,LIVIVO) 进行了范围审查.
- 包括系统审查,实验研究和临床数据在英语和德语.
- 搜索没有时间限制.
主要成果:
- 确定了1979年至2022年间出版的49篇符合条件的文章.
- 证实了哺乳动物内耳结构中巨细胞,淋巴细胞,白细胞和乳腺细胞的存在.
- 在各种物种的稳定状态条件下观察到这些免疫细胞.
结论:
- 目前尚不清楚常驻免疫细胞在健康的耳中的生理作用.
- 需要进一步的基础研究来阐明它们的功能.
- 了解这些细胞对于开发用于内耳疾病的新疗法至关重要.
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