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先进的肝芯片模型用于评估药物代谢和肝毒性

Sonia Frojdenfal1, Agnieszka Zuchowska1

  • 1Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warszawa, Poland.

Biosensors
|September 27, 2024
PubMed
概括

一个新的器官芯片肝脏模型准确地模仿了体内肝脏功能,包括药物代谢. 这种先进的体外模型可以全面评估药物的疗效和直接的细胞效应.

关键词:
3D细胞模型 3D细胞模型毒性毒性毒性毒性毒性毒性毒性毒性毒性毒性毒这是一种水凝.肝脏代谢 肝脏代谢肝脏在一个芯片.

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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
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