慢性压力和代谢失调在炎症性肠病中的神经生物学影响
Aleksandar Sic1,2, Kiana Cvetkovic1, Eshanika Manchanda1
1Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA.
Diseases (Basel, Switzerland)
|September 27, 2024
概括
慢性压力会增加皮质醇,影响代谢健康和神经生物学. 这可能会恶化炎症性肠道疾病 (IBD) 和认知功能,突出需要治疗策略.
科学领域:
- 神经生物学 神经生物学 神经生物学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 慢性压力在现代社会显著影响身体和心理健康.
- 皮质醇是一种关键的压力激素,对于急性压力至关重要,但在慢性上升时有害.
- 下垂体-垂体-上腺 (HPA) 轴控制皮质醇的产生,影响新陈代谢,免疫力和神经生物学.
研究的目的:
- 探索慢性压力的神经生物学影响.
- 研究皮质醇失调对代谢障碍的影响,特别是炎症性肠病 (IBD).
- 阐明连接慢性压力,皮质醇,代谢健康和神经生物学功能的机制.
主要方法:
- 审查关于慢性压力,皮质醇,HPA轴功能以及代谢/神经生物学结果的现有文献.
- 分析皮质醇,葡萄糖皮质类受体和疾病发病之间的相互作用.
- 关于皮质醇升高与IBD,认知障碍和精神疾病等疾病之间的关联的综合数据.
主要成果:
- 长期升高的皮质醇与不良健康影响有关,包括代谢失调.
- 皮质醇失调会加剧炎症性肠道疾病 (IBD),并导致神经退行性过程.
- 慢性压力和相关的荷尔蒙失衡会损害认知功能,增加精神病的易感性.
结论:
- 慢性压力和皮质醇失调显著影响代谢健康和神经生物学功能.
- 了解这些机制为潜在的治疗干预提供了见解与压力相关疾病的治疗干预.
- 准HPA轴和皮质醇通路可能会减轻慢性压力对IBD和神经健康的不良影响.
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