前期卵巢癌手术的术后并发症及其对化疗的影响 延迟化疗
Julia Heikkinen1, Henna Kärkkäinen1, Marja-Liisa Eloranta2
1Department of Obstetrics and Gynecology, Kuopio University Hospital, 70210 Kuopio, Finland.
Current oncology (Toronto, Ont.)
|September 27, 2024
概括
对于晚期卵巢癌进行广泛的手术会增加并发症,但化疗延迟很罕见. 主要脱皮手术 (PDS) 后的大多数并发症是可以管理的,允许及时的辅助治疗.
科学领域:
- 妇科瘤学 妇科瘤学
- 手术瘤学手术瘤学
- 临床研究 临床研究
背景情况:
- 晚期上皮卵巢癌的治疗往往涉及到初级排卵手术 (PDS).
- 广泛的PDS可能会导致术后发病率增加,可能会延迟或省略辅助化疗.
- 评估手术程度对并发症和治疗的影响至关重要.
研究的目的:
- 在先进的上皮卵巢癌中检查一次性脱皮手术 (PDS) 后的术后并发症.
- 评估手术程度 (广泛与标准) 对并发症率和辅助治疗的影响.
主要方法:
- 对172名患有IIIC-IV期上皮卵巢癌的患者进行PDS后期分析 (2013年1月 - 2020年12月).
- 患者分为"广泛" (n=119) 或"标准" (n=53) 的手术组.
- 克拉维恩-丁多3级+ (CDC 3+) 并发症率和化疗延迟的组间比较.
主要成果:
- 与标准手术组 (17%) 相比,在广泛手术组 (41.2%) 中观察到较高的CDC 3+并发症率 (p=0.002).
- 流是最常见的严重并发症.
- 广泛和标准手术组之间的化疗延迟没有显著差异 (p=0.98).
结论:
- 术后并发症在晚期卵巢癌PDS后很常见.
- 虽然广泛的手术会增加并发症的风险,但有效的管理可以最大限度地减少治疗延迟.
- 辅助治疗很少受到PDS后的并发症的影响.
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