设计和评估新的基于凝的浮动矩阵片,使用升华技术为胃药物输送
Worawut Kriangkrai1,2, Satit Puttipipatkhachorn3, Pornsak Sriamornsak4
1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.
Gels (Basel, Switzerland)
|September 27, 2024
概括
这项研究开发了基于升华的浮动矩阵平板电脑,用于使用西奥菲林增强胃药物输送. 优化的药片实现了持续的浮力和受控的药物释放,从而推进了药物输送系统.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 胃药物输送旨在延长药物在胃中的停留时间,以提高治疗效果.
- 浮动矩阵片为胃保持提供了一个有希望的方法,但实现最佳浮力和药物释放仍然是一个挑战.
研究的目的:
- 制定和评估一种基于凝的浮动矩阵片,使用升华技术来增强胃药物输送.
- 调查潜化剂和聚合物粘度对药片性能和药物释放动力学的影响.
主要方法:
- 基于凝的浮动矩阵片剂的配方,其中包括无水神素,基甲基纤维素 (HPMC) 和升华剂 (碳酸,薄荷).
- 评估药片特征,包括孔隙性,浮力 (漂浮时间和持续时间),机械强度和体外药物释放.
- 优化配方参数,以实现所需的浮动行为和持续的药物释放概况.
主要成果:
- 通过升华技术,成功地制造出具有立即和持续浮力 (>8小时) 的多孔片.
- 调整HPMC粘度和升华剂度调节了浮动行为和药物释放.
- 与薄荷相比,碳酸产生了优越的药片硬度和受控释放.
- 理论蛋白释放遵循异常 (非Fickian) 扩散模型,表明扩散和侵蚀机制的结合.
结论:
- 基于升华的浮动矩阵片是有效的 gastroretentive 传递的 theophylline.
- 使用HPMC粘度和升华剂的配方优化允许量身定制的浮力和持续的药物释放.
- 这项技术在开发先进的胃补充药物输送系统方面具有重大潜力.
相关概念视频
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