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在计算生物学时代的直接心脏重编程

Rachelle Ambroise1,2,3, Paige Takasugi2,3, Jiandong Liu2,3

  • 1Department of Bioinformatics and Computational Biology, University of North Carolina, Chapel Hill, NC 27599, USA.

Journal of cardiovascular development and disease
|September 27, 2024
PubMed
概括

直接的心脏重编程将痕组织转化为新的心脏细胞,为心脏病提供了一个有希望的解决方案. 计算工具正在加速这种再生医学方法的临床应用.

关键词:
生物信息学是一种生物信息学.计算生物学是计算生物学.通过直接的心脏重编程.

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Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.