用分子方法进行表征的美国菌病流行病学,2015-2024年
Aditya K Gupta1,2, Tong Wang2, Shruthi Polla Ravi2
1Division of Dermatology, Department of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 3H2, Canada.
Journal of fungi (Basel, Switzerland)
|September 27, 2024
概括
准确识别指甲真菌 (onychomycosis) 对于有效治疗至关重要. 分子诊断揭示了更广泛的病原体,包括非皮肤菌菌和酵母菌,影响治疗策略.
科学领域:
- 菌类学 菌类学是指菌类学.
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 甲状腺炎是一种常见的,难以治疗的指甲真菌感染.
- 准确的病原体鉴定对于成功治疗和预防并发症至关重要.
- 传统的诊断方法可能无法捕获病原体的全部谱.
研究的目的:
- 通过分子诊断在大量患者队列中分析指甲病原体的光谱.
- 调查与特定的真菌和酵母菌感染的人口和临床关联.
- 为了比较由不同类型的病原体引起的桃菌的呈现.
主要方法:
- 在2015年至2024年期间通过PCR测试的710,541个指甲标本的回顾性分析.
- 分子发现与组织病理学的相关性.
- 基于患者的人口统计 (性别,年龄) 和临床表现 (表面,消极,下) 的病原体流行情况的统计分析.
主要成果:
- 通过PCR检测发现了广泛的病原体,包括皮肤菌 (例如,T. rubrum*复合体,54.3%),非皮肤菌菌 (NDMs) (例如,Aspergillus*,7.0%;Fusarium*,4.5%) 和酵母 (例如,Candida*物种).
- 女性的NDM和酵母菌感染率更高. 随着年龄的增长, *T. mentagrophytes* 复合物的患病率增加,而 *T. rubrum* 复合物的患病率减少.
- 年长的成年人 (≥65岁) 患NDM感染的可能性更高. NDMs和酵母与表面桃菌根症更为相关,而皮质植物更与缩性形式有关.
结论:
- 分子诊断提供了比以前理解的更全面的病原体概况.
- 性别和年龄等人口因素与特定类型的指甲真菌感染有关.
- 了解病原体的谱和它们的临床关联可以指导有针对性的治疗选择,并改善患者的治疗结果.
关键词:
皮肤植物病 (dermatophytosis) 是一种组织病理学 组织病理学分子诊断 分子诊断 分子诊断菌类学 菌类学是指菌类学.基菌菌症是什么丁娜·恩格尤姆 (英语:Tinea Unguium) 是一个名字.更多相关视频
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