外周脂质特征,代谢功能障碍和精神分裂症谱系障碍中的病理生理学
Sally Wu1,2, Kristoffer J Panganiban1,2, Jiwon Lee1,2
1Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON M6J 1H3, Canada.
Metabolites
|September 27, 2024
概括
精神分裂症谱系障碍 (SSD) 中的代谢功能障碍涉及改变的脂质代谢. 这次审查发现,在接触抗精神病药物 (AP) 最少的患者和接受AP治疗的患者中,特定的脂质变化,表明脂质.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 代谢功能障碍是精神分裂症谱系障碍 (SSD) 中常见的并发症.
- 原因是多因素的,包括与疾病相关的内在因素和抗精神病药物 (AP) 副作用.
- 不调节的脂质代谢是SSD病理生理学和AP诱导的代谢问题的潜在潜在机制.
研究的目的:
- 系统地审查 SSD 个体中调节失调的外周脂质特征.
- 分析SSD患者的脂质变化,与接受AP治疗的患者相比,SSD患者的AP暴露最小.
- 在SSD中识别特定的脂质代谢物及其失调模式.
主要方法:
- 在SSD患者中使用脂管药物的研究的系统审查.
- 在2024年2月搜索了MEDLINE,Embase和PsychINFO数据库.
- 与对照组或治疗阶段相比,提取了明显不同的脂质特征及其调节失调的方向.
主要成果:
- 46项研究符合纳入标准.
- 在极少暴露于AP的SSD患者中,糖脂主要是下调调节的.
- 在接受AP治疗的SSD患者中,脂肪乙基体表现出相互矛盾的失调;糖脂和脂肪乙基体在治疗前后发生变化.
结论:
- 周围脂质失调在SSD中显而易见,无论是用AP治疗还是没有AP治疗.
- 特定的脂类,如甘氨酸脂和脂肪酸,可能在SSD病理生理学中起作用.
- 这些改变的脂质可能会影响炎症,细胞透性和代谢信号,导致代谢功能障碍.
相关概念视频
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
513
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
513
01:29Biological Causes of Schizophrenia
50
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
50
01:30Negative and Cognitive Symptoms of Schizophrenia
46
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
46
01:24Overview of Lipid Metabolism
1.1K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.1K
01:30Positive Symptoms of Schizophrenia: Hallucinations and Delusions
69
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
69
01:29Psychological and Sociocultural Causes of Schizophrenia
80
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
80