自然产品和衍生品针对结肠直肠癌中的代谢重编程:全面审查
Mengyu Wang1,2, Liqun Qu2,3, Xinying Du2,3
1Nehr's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
Metabolites
|September 27, 2024
概括
天然产品在向结肠直肠癌 (CRC) 的代谢重编程方面表现有前途. 这些化合物可以破坏关键的代谢途径,为CRC和相关的代谢疾病提供新的治疗途径.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 代谢重编程是结直肠癌 (CRC) 进展的关键驱动因素.
- 癌细胞改变其新陈代谢以支持快速生长和扩散.
- 天然产品正在研究其抗癌特性和克服化学抵抗的能力.
研究的目的:
- 审查最近在自然产品干预中取得的进展,针对CRC中的代谢重编程.
- 提供自然产品如何影响CRC细胞中关键代谢途径的概述.
- 突出自然产品在CRC治疗中的治疗潜力.
主要方法:
- 1980年1月至2023年10月发表的研究的系统文献综述.
- 从科学网和PubMed数据库收集的数据.
- 专注于五个代谢方面:葡萄糖代谢,线粒体氧化酸化 (OXPHOS),氨基酸代谢,脂肪酸合成和核酸代谢.
主要成果:
- 天然产品在破坏CRC中的关键代谢途径方面具有潜力.
- 干预措施的目标是改变葡萄糖,氨基酸,脂肪酸和核酸代谢.
- 自然产品可以抵消与CRC中代谢变化相关的化学抵抗.
结论:
- 自然产品代表了一种有前途的治疗策略,用于针对结直肠癌中的代谢重编程.
- 对天然产品衍生化合物的进一步研究可以扩大CRC的治疗选择.
- 这一综述强调了天然产品在治疗癌症中的代谢相关疾病方面的潜力.
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