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功能性蛋糕对人类肠道微生物群具有双原性作用,同时对人类肠道微生物群具有高度产品特异性作用

Stef Deyaert¹, Jonas Poppe¹, Lam Dai Vu¹

¹Cryptobiotix, Technologiepark-Zwijnaarde 82, 9052 Ghent, Belgium.

|September 27, 2024

概括

含有益生菌和益生菌的GoodBiomeTM食品显著改变了肠道微生物组. 这些功能性食物增加了有益的短链脂肪酸 (SCFA) 和抑制病原体,表明对肠道健康产生积极影响.

科学领域:

微生物学微生物学
人类肠道微生物组研究研究
营养科学营养科学

背景情况:

功能性食品通过调节肠道微生物群来提供有针对性的健康益处.
益生菌如 Bacillus subtilis HU58TM 和益生菌如胰岛素是肠道健康的关键组成部分.
了解复杂的食物矩阵对微生物群的影响,需要生理学上相关的模型.

研究的目的:

评估GoodBiomeTM食品 (BBM/LCM/OSM) 对人类肠道微生物组的影响.
评估益生菌和益生菌在调节肠道微生物组成和代谢物产生中的作用.
研究食品成分对特定细菌物种丰富度和短链脂肪酸 (SCFA) 生产的影响.

主要方法:

使用了ex vivo SIFR®技术,经过临床预测见解的验证.
接受GoodBiomeTM食品模拟的口腔,胃和小肠消化/吸收.
评估了四名成年参与者的肠道微生物组的影响 (n=3).

主要成果:

所有GoodBiomeTM食品增加了有益的SCFA:乙酸,酸 (特别是OSM),酸 (特别是BBM).
观察到有益细菌的显著增加,包括Bifidobacterium物种,Coprococcus catus和Bacteroidetes成员.
OSM和BBM配方显示抑制了致病原体Clostridioides difficile,可能与细菌HU58TM有关.

结论:

功能性食品中的特定成分可以精确调节肠道微生物群,提供潜在的健康优势.
这项研究强调了生理学上相关的消化模型对体外方法对于准确的微生物组评估的重要性.
通过微生物调节和代谢物增强,GoodBiomeTM食品在促进更健康的肠道环境方面表现有前途.

关键词:

果爆发饼干 (BBM) 是一个很好的方法.功能性食品是一种功能性食品.chia 饼干 (LCM) 是一种麦香料莫基 (OSM) 是一种益生菌益生菌益生菌益生菌是一种益生菌.短链脂肪酸 (SCFA) 是一种短链脂肪酸.系统性肠道发酵研究 (SIFR)

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