草和蓝摄入量的尿路生物标志物
Ya Gao1,2, Rebecca Finlay1,2, Xiaofei Yin1,2
1Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.
Metabolites
|September 27, 2024
概括
研究人员发现了果消费的新尿路生物标志物. 这项研究为开发测量果摄入量的准确工具提供了基础,克服了自我报告方法的局限性.
科学领域:
- 营养生物化学 营养生物化学
- 代谢学 代谢学 代谢学
- 发现生物标志物的发现.
背景情况:
- 像自我报告这样的饮食评估方法有显著的局限性.
- 需要准确的食品生物标志物来客观地测量营养素摄入量.
- 果在全球范围内很重要,但缺乏有效的摄入生物标志物.
研究的目的:
- 识别和验证特定于果消费的尿路生物标志物.
- 建立一个开发果摄入量的客观措施的基础.
主要方法:
- 采用非向的液体染色学-质谱学 (LC-MS) 代谢学.
- 使用发现和剂量反应研究,控制果消费 (草和蓝).
- 分析了在消费后的不同时间点收集的尿样.
主要成果:
- 确定了21个显著的尿路生物标志物,显示了对果摄入剂量依赖的反应.
- 在消费后检测到54种代谢物特征 (39种消极模式,15种积极模式) 的显著增加.
- 在多个数据库和真实标准中使用光谱匹配确认生物标志物身份.
结论:
- 成功确定了一组用于果摄入的尿路生物标志物.
- 开发的生物标志物小组证明了评估果消费的良好可预测性.
- 这项研究为未来开发客观饮食评估工具奠定了基础.
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