心肺健康的代谢预测者 持续耐力和高强度间歇训练计划的反应能力:泰士研究-随机对照试验
Alex Castro1,2,3, Antonio Gilberto Ferreira3, Aparecida Maria Catai4
1Biosciences National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas 13083-100, SP, Brazil.
Metabolites
|September 27, 2024
概括
通过使用基线血液和肌肉代谢物,可以预测运动带来的心肺健康 (CRF) 益处. 血清O-乙卡尼丁和肌肉内肌可以将个人分类为对训练有反应或没有反应的人.
科学领域:
- 运动生理学 运动生理学
- 代谢学 代谢学 代谢学
- 个性化医疗是个性化的医疗.
背景情况:
- 心血管健康 (CRF) 对健康至关重要,但个体对运动的反应有很大差异.
- 了解这些变化可以导致个性化的运动处方.
- 识别运动反应的生物标志物是推动运动医学发展的关键.
研究的目的:
- 为了确定心肺健康 (CRF) 响应能力的预测生物标志物.
- 根据基线代谢概况,将个人分为耐力训练 (ET) 或高强度间歇训练 (HIIT) 的响应者或不响应者.
- 评估血清和肌肉内代谢物作为CRF增长的预测因素.
主要方法:
- 70名久坐不动的年轻人接受了为期8周的ET,HIIT或对照期.
- 使用质子核磁共振 (1H NMR) 分析了血清和肌肉内 (vastus lateralis) 代谢物.
- 心肺呼吸能力 (CRF) 在基线和干预后被测量;多变量逻辑回归被用于分类.
主要成果:
- 血清O-乙卡尼丁预测了CRF响应率,准确率为78.0%,无论训练类型如何.
- 肌肉内肌素预测了CRF响应率,准确度为72.3%.
- 这两种生物标志物都通过多变量逻辑回归模型来确定.
结论:
- 血清和肌肉内代谢物显示出作为CRF响应性的预测生物标志物的潜力.
- 这些发现支持开发个性化的有氧训练计划.
- 代谢物分析可以帮助分类个体适应运动干预的适应性.
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