和多基基物质 (PFAS) 影响女性生殖健康:流行病学证据和潜在机制
Rui Qu1, Jingxuan Wang1, Xiaojie Li2
1Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Toxics
|September 27, 2024
概括
和多基物质 (PFAS) 通过各种途径污染环境和人体. 本审查审查了它们的生殖毒性和潜在机制,突出了对女性生殖健康的担忧.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 生殖健康 生殖健康
背景情况:
- 和多基基物质 (PFAS) 是工业和消费品中广泛使用的持久,移动化学品,导致环境无处不在.
- 人类暴露于PFAS发生在多种途径上,包括皮肤接触,水,空气和饮食.
- 尽管逐步淘汰了一些PFAS,但传统和替代化学品的混合物仍然存在环境和健康风险.
研究的目的:
- 提供PFAS来源和暴露途径的全面概述.
- 审查PFAS记录的生殖毒性,特别是在女性生殖健康方面.
- 探索PFAS诱导的生殖毒性背后的潜在机制.
主要方法:
- 关于PFAS的毒理学和流行病学研究的文献综述.
- 分析PFAS的环境持久性和流动性.
- 关于PFAS对女性生殖健康结果的影响的综合研究.
- 研究PFAS毒性的拟议生物机制.
主要成果:
- 暴露于PFAS与各种不利的女性生殖健康结果有关,包括PCOS,过早的卵巢衰竭,子宫内膜异位症,瘤和妊娠并发症.
- 现有的关于PFAS生殖毒性的研究结果是不一致的,而且机制仍然不太清楚.
- 该审查综合了各种暴露途径及其对毒理效应的贡献的证据.
结论:
- 由于其持久性和广泛存在,PFAS对女性生殖健康构成重大威胁.
- 进一步的研究至关重要,以阐明PFAS生殖毒性的机制,并为公共卫生战略提供信息.
- 了解PFAS来源,途径和毒理影响对于降低风险至关重要.
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