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对细胞外囊泡临床试验的批判性系统审查

Rachel R Mizenko¹, Madison Feaver¹, Batuhan T Bozkurt¹

¹Department of Biomedical Engineering, University of California, Davis, California, USA.

Journal of extracellular vesicles

|September 27, 2024

概括

细胞外囊泡 (EV) 临床试验正在扩大,癌症的诊断是最常见的. 治疗常常使用介酶体 stromal cell (MSC) EVs用于呼吸系统疾病,但报告和EV亚群分析需要改进以获得更好的翻译.

科学领域:

生物医学研究的研究.
翻译医学是一种翻译医学.
临床试验分析临床试验分析

背景情况:

细胞外囊泡 (EVs) 越来越多地被用于临床应用.
了解电动汽车临床试验的当前趋势对于推进该领域至关重要.
为了提高翻译成功,需要专注于EV子群和方法.

研究的目的:

系统地审查与EV相关的临床试验.
阐明临床应用和方法的趋势.
评估EV亚群的认可和利用情况.

主要方法:

对公开报告存储库的系统审查.
列出了471个与EV相关的临床试验.
分析疾病的表征,应用和方法.

主要成果:

针对200多种疾病,癌症的诊断是最常见的.
介酶体 stromal cell (MSC) EVs 在呼吸治疗中很常见.
超离心和RNA测序很普遍,但往往报道很少;只有11%的人使用了EV亚群.

结论:

EV临床试验显示出显著的增长,特别是在诊断和MSC-EV治疗方面.
不一致的方法报告和有限的EV亚群使用阻碍了转化进展.
未来的研究应该强调详细的报告和针对个性化医学的EV亚群的战略使用.

关键词:

诊断诊断诊断诊断诊断提供毒品的车辆.外基因组是外基因组的组成部分.异质性的异质性治疗药物治疗药物

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