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Updated: Jun 11, 2025

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

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VPS13B位于戈尔吉水箱之间的接口,是FAM177A1的功能合作伙伴

Berrak Ugur1,2,3,4,5, Florian Schueder1,6, Jimann Shin7

  • 1Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

The Journal of cell biology
|September 27, 2024
PubMed
概括

科恩综合征与影响脂质运输的VPS13B突变有关. 这项研究揭示了VPS13B.

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Golgi Matrix Proteins

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Transport Across the Golgi

While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
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Coat Assembly and GTPases

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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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GPI Anchoring of Proteins in the ER Membrane

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GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
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