ACTN3 R577X多态性对最大偏心运动后血清肌酸激酶和白蛋白-6水平的影响
Minoru Deguchi1, Hiroki Homma, Kathleen Y de Almeida
1From the Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan (MD, KYD, AK, MS, TO, KN, NK); Faculty of Sport Science, Nippon Sport Science University, Tokyo, Japan (HH, TO, NK); Laboratory of Health and Sports Sciences, Meiji Gakuin University, Kanagawa, Japan (YT); Faculty of Medical Science, Nippon Sport Science University, Kanagawa, Japan (KK, KN); and Faculty of Bioscience and Applied Chemistry, Hosei University, Tokyo, Japan (EO).
American journal of physical medicine & rehabilitation
|September 27, 2024
概括
ACTN3 R577X基因变异影响运动后的肌酸激酶水平,特别是在缺乏ACTN3的个体中. 这种遗传因素会影响肌肉损伤标志物,但不会影响炎症反应.
科学领域:
- 运动生理学 运动生理学
- 人类遗传学 人类遗传学
- 运动科学 运动科学
背景情况:
- ACTN3基因提供了制造α-actinin-3的指令,α-actinin-3是骨肌中发现的蛋白质.
- R577X多态 (rs1818101) 影响了α-actinin-3的存在,XX基因型与其缺乏相关.
- 了解基因对肌肉损伤和恢复的影响对于优化训练和预防伤害至关重要.
研究的目的:
- 研究ACTN3 R577X多态性和运动后肌肉损伤和炎症标志物之间的关系.
- 为了确定ACTN3 (XX基因型) 的缺失是否会影响异常运动后的肌酸酶和介质素-6水平.
主要方法:
- 95名活跃的日本参与者接受了最大的偏心肘部曲练习.
- 评估运动前和运动后 (长达5天) 的肌肉损伤 (肌酸激酶,疼痛),功能 (MVC,ROM) 和炎症 (互白素-6).
- 参与者被基因型为ACTN3 R577X多态,分为RR+RX和XX组.
主要成果:
- 对于肌酸酶水平 (P=0.045) 发现时间和基因型之间的显著相互作用,表明ACTN3缺席会影响其变化.
- 与RR+RX组相比,XX基因型组在运动后表现出较高的肌酸激酶活性.
- 没有观察到针对interleukin-6,MVC,ROM或肌肉疼痛的显著基因型特定相互作用.
结论:
- 在异常运动后,ACTN3 R577X多态性显著影响肌酸激酶反应.
- 具有XX基因型 (没有ACTN3) 的个体表现出更高的肌酸激酶水平,这表明肌肉损伤反应中的作用.
- 在这个队列中,ACTN3基因型似乎没有调节运动后炎症反应 (IL-6) 或功能恢复.
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