来自北印度的块性皮肤病病毒的流行病学,遗传特征和人口结构分析
Pallavi Moudgil1, Ramesh Kumar1, Punit Jhandai1
1Department of Veterinary Public Health and Epidemiology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India, 125004.
Tropical animal health and production
|September 27, 2024
概括
研究了印度的皮病 (LSD) 爆发情况. 对型皮肤病病毒 (LSDVs) 的基因分析揭示了与以前的菌株的密切关系,这表明最近的人口扩张并为控制策略提供了信息.
科学领域:
- 兽医病毒学 兽医病毒学
- 流行病学 流行病学
- 分子生物学分子生物学
背景情况:
- 凸轮性皮肤病 (LSD) 是一种影响畜牧业经济的重大跨境病毒性牛病.
- 上一篇 型皮肤病病毒 (LSDV) 菌株在印度传播,需要持续监测.
研究的目的:
- 调查2022年在印度爆发的突发性皮肤病病毒 (LSDV) 疫情.
- 执行循环LSDV菌株的流行病学和遗传特征.
- 分析LSDV的种群结构和动态.
主要方法:
- 在哈里亚纳邦,希马查尔邦和拉贾斯坦邦LSD疫情的流行病学调查.
- 从牛样本中分离和对LSDV进行遗传鉴定.
- 使用P32和EEV基因序列进行了家族遗传学分析.
- 多个序列对齐和EEV基因的中间连接网络分析.
主要成果:
- 在138个可疑的牛样本中,有106个为LSDV阳性.
- 遗传学分析显示,在2022年和2019年印度LSDV菌株之间具有高核酸标识 (99.10-100%).
- 分析确定了循环LSDV/2022菌株EEV基因中的三个核酸多态.
- 人口结构分析显示了高的单元型多样性和低的核酸多样性,这表明最近的LSDV扩张.
结论:
- 印度2022年LSDV菌株与以前的菌株密切相关.
- 有证据表明,研究区域的LSDV种群最近扩大.
- 了解LSDV动态对于开发有效的疾病管理和控制策略至关重要.
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