儿童桃腺炎的A组链球菌测试阳性和临床发现之间的关系:系统性审查和元分析
Ayşe Eroğlu1, Özge Karakaya Suzan2, Tuğçe Kolukısa3
1Department of Nursing, Institute of Health Sciences, Sakarya University, Esentepe Campus, Serdivan, Sakarya, 54187, Turkey. ayseeroglu@sakarya.edu.tr.
Infection
|September 27, 2024
概括
甲型 estreptococcus (GAS) 喉炎通常是由桃体排泄物, palatal petechiae 和发烧表示的. 这次元分析发现,头痛和咳等症状不是GAS感染的可靠指标.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- A组β-溶血性链球菌 (GAS) 是常见的炎的细菌原因.
- 准确诊断GAS喉炎对于预防并发症和指导抗生素治疗至关重要.
- 临床迹象和症状通常用于初步评估,但其诊断准确性各不相同.
研究的目的:
- 系统地分析和综合证据,以区分与确诊的GAS喉炎相关的临床症状和体征.
- 通过喉培养或快速检测证实,比较与GAS感染有关的各种症状的诊断效用.
- 提供基于证据的结论,以帮助临床诊断链球菌喉炎.
主要方法:
- 进行了一项系统的元分析,遵循已发表的协议 (PROSPERO CRD42023450854).
- 2013年1月至2023年8月间发表的研究在七个数据库中进行了系统的搜索.
- 使用JBI检查清单评估方法质量,使用固定和随机效应模型计算效应大小.
主要成果:
- 系统性审查包括22篇文章,其中14篇文章为分析做出了贡献.
- 链球菌喉炎的患病率在包括的研究中从7.3%到44.1%不等.
- 在GAS阳性和桃体排泄物, palatal petechiae,桃体缩,消化不良,发烧和宫淋巴腺症 (p <0.05) 之间发现了显著的关联.
结论:
- 口腔,消化不良和桃体缩是GAS感染的重要指标,补充了Centor标准.
- 头痛,喉疼痛,咳,吐和鼻等症状在本次元分析中与GAS感染没有显著的关联.
- 建议进行进一步的研究,以充分阐明GAS喉炎中各种临床表现的诊断价值.
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