血红蛋白病变与男性不孕症之间的关系:一个范围审查
Abdullah M Al-Jubouri1, Ahmed Eliwa2, Yunes Haithm2
1College of Medicine, QU Health, Qatar University, 2713, Doha, Qatar. aa1901512@qu.edu.qa.
International journal of hematology
|September 27, 2024
概括
血性疾病,如状细胞病和大血症,可以通过损害红细胞氧气运输,导致男性不孕. 输血可以通过解决潜在的疾病来帮助缓解这种不孕症.
科学领域:
- 血液学 血液学 血液学
- 生殖医学 生殖医学
- 遗传学 遗传学 是一个
背景情况:
- 不孕症在全球范围内影响着夫妇,男性因素的贡献很大.
- 系统性健康问题,包括血液病,是不孕不育的已知原因.
- 血球蛋白病变,如状细胞病 (SCD) 和大血病 (TM) 都与男性不孕症有关.
研究的目的:
- 调查SCD和TM与男性不孕症之间的联系.
- 阐明连接血红蛋白病与不孕不育的病理生理机制.
- 探索输血在治疗与这些疾病相关的不孕症方面的治疗潜力.
主要方法:
- 对有关血红蛋白病变和男性不孕不育的现有文献的综述.
- 分析涉及红细胞功能和精子生成的病理生理路径.
- 检查治疗策略,特别是输血.
主要成果:
- SCD和TM损害了红细胞的氧气承载能力,导致组织缺氧.
- 缺氧会对精子生成产生负面影响,这是男性生育能力的关键过程.
- 输血有可能纠正潜在的血液问题,从而改善生育能力.
结论:
- 血球蛋白病是通过诱导缺氧导致男性不孕症的重要贡献者.
- 了解这些机制对于诊断和管理至关重要.
- 输血为与SCD和TM相关的不孕症提供了一种可行的治疗方法.
相关概念视频
Infertility in Males
253
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
253
Spermatogenesis
102.2K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.2K
Blood Transfusion and Agglutination
10.7K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.7K
Infertility in Females
288
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
288
Sex-linked Disorders
101.7K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
101.7K
Rh Blood Group
1.4K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.4K


