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Updated: Jun 11, 2025

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在亨廷顿病中,多ADP-ribose信号失调

Tamara Maiuri1, Carlos Barba Bazan1, Rachel J Harding2,3,4

  • 1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 3Z5, Canada.

Proceedings of the National Academy of Sciences of the United States of America
|September 27, 2024
PubMed
概括

亨廷顿病 (HD) 涉及DNA损伤和改变的多 (ADP-ribose) (PAR) 水平. 突变的亨廷丁蛋白影响了PARP1的活动,这表明了早期干预的新治疗点.

关键词:
亨廷顿病就是亨廷顿病.PARP1 的第一部分这是一种PARylation.狩猎 狩猎 狩猎 狩猎聚ADP-核糖的多 ADP-核糖.

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