轨道前皮层中决策变量的表示在纵向上是稳定的
Manning Zhang1, Alessandro Livi2, Mary Carter2
1Department of Neuroscience, Washington University in St. Louis, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA.
轨道前皮层 (OFC) 神经电路随着时间的推移而稳定,神经元始终编码决策变量. 这种稳定性表明,OFC为经济决策回路奠定了坚实的基础.
科学领域:
- 神经科学是一个神经科学.
- 决策科学 决策科学 决策科学
- 计算神经科学是一种神经科学.
背景情况:
- 轨道前皮层 (OFC) 对于经济决策至关重要,它可以处理选择的主观价值.
- 在OFC中的不同的神经元群体编码选择输入和输出,形成潜在的决策电路.
研究的目的:
- 在基于价值的选择任务中,调查OFC内的神经元表示的纵向稳定性.
- 为了确定选择变量的神经元编码是否在长时间内保持一致.
主要方法:
- 在执行果汁选择任务的小鼠中利用两光子成像.
- 在40周内记录了来自单个轨道前皮层神经元的神经活动.
- 分析了神经元活动概况,使用共弦相似度来评估表示稳定性和漂移.
主要成果:
- 在OFC神经元活动和决策变量编码中表现出高纵向稳定性.
- 观察到适度的表示漂移,不太可能在动物的寿命内随机化电路.
- 识别出不同的神经元组编码选项值,选择结果和选择值.
结论:
- 轨道前皮层内的神经回路在纵向上是稳定的,支持其作为基本决策回路的作用.
- 观察到的表示漂移是缓慢的,表明主观值的可靠编码随着时间的推移.
- 这些发现支持了OFC中特定细胞组作为经济选择计算的基石的假设.
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