3D打印在个性化药物和药物查中的当前发展和进步
Megha Tonk1, Vishal Gupta1, Amar Dhwaj2
1Raj Kumar Goel Institute of Technology (Pharmacy), Ghaziabad, Uttar Pradesh, India.
Drug metabolism and personalized therapy
|September 27, 2024
概括
三维打印 (3DP) 是一种增材制造 (AM) 技术,为制药应用提供高效和成本效益的解决方案. 本综述探讨了创建剂型和推进个性化医疗的3DP技术.
科学领域:
- 制药科学 制药科学
- 制造业 制造技术 制造技术
- 生物技术是生物技术.
背景情况:
- 三维打印 (3DP) 是一种增材制造 (AM) 的形式,由于其成本效益和效率,正在迅速扩大.
- 全球3D打印市场预计到2026年将达到372亿美元,显示出行业的显著增长.
- 在主要的学术数据库中,对3DP技术和创新药物输送系统的研究兴趣日益增加.
研究的目的:
- 审查适用于制药应用的关键3DP技术.
- 专注于具有监管接受度和商业制造可行性的3DP系统.
- 讨论3DP在药物输送和药物查中的应用.
主要方法:
- 基于挤出,基于粉末,基于液体和基于板层的3DP系统的审查.
- 对3DP在剂型创建中的药物应用的分析.
- 检查3DP在药物输送和查过程中的作用.
主要成果:
- 确定了适用于药品的四种主要的3DP技术.
- 强调了创造复杂剂型和制药品的潜力.
- 证明了用于商业制造的特定3DP方法的技术可行性和监管接受性.
结论:
- 3D打印对个性化医疗,风险评估和成本效益高的复杂药物配方制造具有重大前景.
- 增材制造即将彻底改变药物制造和利用.
- 对3DP的医学和药理学应用进行进一步的研究是有必要的.
相关概念视频
01:22Biopharmaceutical Factors Influencing Drug Product Design: Overview
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
01:27Drug Delivery Systems: Different Types
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...