接种COVID-19疫苗后的不良事件:加纳自发报告数据的全面分析
Amma Frempomaa Asare1, George Tsey Sabblah1, Richard Osei Buabeng1
1Food and Drugs Authority, Accra, Ghana.
PLOS global public health
|September 27, 2024
概括
这里是加拿大加拿大加拿大加拿大.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 药物监督 药物监督 药物监督
背景情况:
- 在加纳,COVID-19疫苗获得了紧急使用授权.
- 早期的疫苗试验往往排除了非洲人群.
- 需要加纳的真实世界安全数据.
研究的目的:
- 检查加纳部署的COVID-19疫苗的安全概况.
- 为了分析免疫接种后的不良事件 (AEFI) 数据.
- 评估与严重的AEFI相关的因素.
主要方法:
- 对向加纳食品和药物管理局 (GFDA) 报告的二次AEFI数据的分析.
- 从2021年3月到2022年6月收集的数据.
- 使用监管活动医学词典编码的AEFI;使用STATA进行的统计分析.
主要成果:
- AEFI的累计发病率为每10万人中有25人.
- 大多数AEFI (98.7%) 的情况并不严重.
- 常见的AEFI包括头痛,疼痛和发烧症.
- 年轻人 (<50岁) 和女性报告AEFI发病率较高.
- 只有14%的严重AEFI被认为与疫苗产品有关.
结论:
- 在加纳,COVID-19疫苗显示AEFI的发病率较低.
- 严重的不良事件很少发生,并且大多与疫苗无关.
- 关于疫苗安全的公开沟通可以增强信任,减少犹.
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