老年人关节炎与认知功能障碍之间的关联:基于NHANES 2011-2014年
Taihong Lv1, Hanming Yu2, Zishuo Ji3
1Department of General Practice, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
PloS one
|September 27, 2024
概括
关节炎可能与老年人的认知能力下降有关. 这项研究发现,关节炎与认知测试得分较低有关,这表明认知障碍的潜在危险因素.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
背景情况:
- 关节炎是老年人常见的疾病.
- 新出现的证据表明,关节炎和认知障碍 (包括痴呆症) 之间存在潜在联系.
- 了解这种关系对于针对认知衰老的公共卫生倡议至关重要.
研究的目的:
- 为了研究关节炎和认知功能之间的关联,在一个代表性样本的美国成年人60岁及以上.
- 确定关节炎是否是认知能力下降的重要危险因素.
- 分析关节炎患者和没有关节炎患者在不同领域的认知表现.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) 的数据.
- 在2,398名60岁以上的成年人群中使用了后勤回归和立方斜线模型.
- 使用即时回忆测试 (IRT),延迟回忆测试 (DRT),动物流利测试 (AFT) 和数字符号替代测试 (DSST) 评估认知表现.
主要成果:
- 关节炎在12.03%的分析人群中被发现 (2,398人中的19,931人).
- 与没有关节炎的人相比,患有关节炎的人在数字符号替换测试 (DSST) 和动物流利性测试 (AFT) 中得分较低.
- 经过对混因素的调整后,关节炎仍然与认知表现有显著的关联,赔率比表明保护作用或复杂关系 (OR:DSST的0.796,OR:AFT的0.769).
结论:
- 这项研究强调了美国老年人关节炎患病率和认知功能之间存在显著的关联.
- 关节炎可能是一个可修改的风险因素或是认知障碍的标志物.
- 需要进一步的研究,以阐明关节炎-认知联系及其临床影响背后的机制.
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