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混合金属暴露对基底腺的MRI指标的影响
Juhee Kim1, Byoung-Gwon Kim2, Young-Seoub Hong2
1Department of Health Care and Science, Dong-A University, Busan 49315, South Korea.
Toxicological sciences : an official journal of the Society of Toxicology
|September 27, 2024
概括
含有和的接烟雾会影响基底中大脑成像指标. 较高的金属含量与改变的MRI放松时间和扩散张力成像相关,表明混合金属暴露的神经毒性作用.
科学领域:
- 神经成像是一种神经成像.
- 职业健康 职业健康 职业健康
- 毒理学 毒理学 毒理学
背景情况:
- 接烟雾含有多种金属,先前的研究重点是的神经毒性.
- 在接中常见的混合金属暴露对大脑结构和功能的影响仍然不太了解.
研究的目的:
- 为了研究接中混合金属暴露对基底质 (BG) 中磁共振成像 (MRI) 度量的影响.
- 探索特定金属水平和接工人的神经成像结果之间的剂量反应关系.
主要方法:
- 对比的MRI指标 (T1放松时间,扩散张力成像) 在23个接工人和24个对照者的基底腺节.
- 通过问卷和全血金属分析 (包括和) 评估金属暴露.
- 利用基于voxel的形态测量来评估大脑体积.
主要成果:
- 接工人在白球 (GP) 和骨中呈现出改变的MRI指标,包括增加R1,轴向扩散率 (AD) 和平均扩散率 (MD),以及减少分数异构 (FA).
- 接工人血液中 (Mn) 和 (V) 的较高水平与基底腺R1和T1加权 (T1W) 值的增加相关.
- 混合金属暴露对GP T1W和R1值产生了显著影响,GP扩散指标和BG T1W值在某些值以上之间存在非线性关联.
结论:
- 和,单独或作为混合物,与白球体的T1信号发生变化有关.
- 这些金属诱导的变化可能会导致在特定的暴露值之后,基底的扩散张力成像指标发生变化.
- 这项研究强调了接中混合金属暴露对大脑结构和功能的潜在神经毒性影响.
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