空气污染物与精神疾病的关联:一个双样本的门德尔随机化
Yuan-Yuan Ma1, Qiong-Yan Li1, An-Yu Shi1
1Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing 400042, China; Chongqing Key Laboratory of Ageing and Brain Diseases, Chongqing 400042, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing 400042, China.
Ecotoxicology and environmental safety
|September 27, 2024
概括
包括NO2和PM2.5在内的空气污染暴露与严重抑郁症,双相情感障碍和注意力缺陷多动性障碍的风险增加有关. 减轻空气污染对于减少精神疾病发病率至关重要.
科学领域:
- 环境健康 环境健康
- 精神病学遗传学 精神病学遗传学
- 流行病学 流行病学
背景情况:
- 越来越多的证据将空气污染与精神疾病联系在一起,但因果关系仍然不清楚.
- 研究各种空气污染物对心理健康的具体影响至关重要.
研究的目的:
- 确定暴露于特定空气污染物和发展各种精神疾病的风险之间的因果关系.
- 利用遗传数据和先进的统计方法来确定因果关系.
主要方法:
- 使用两个样本的门德尔随机化 (MR) 分析.
- 用英国生物库的空气污染物 (NOx,NO2,PM2.5,PM2.5-10,PM10) 相关的单核酸多态 (SNPs) 作为仪器变量.
- 分析了来自大型联盟的大型抑郁症,焦虑症,双相情感障碍,精神分裂症,PTSD,ADHD,ASD,神经性厌食症和强迫症的总结级数据.
主要成果:
- 基因预测的NO2暴露显示了与严重抑郁症,双相情感障碍,精神分裂症,多动症和自闭症谱系障碍的风险增加的因果关系.
- 暴露于PM2.5与较高的抑郁症,双相情感障碍和ADHD风险有因果关系.
- 氧化物和PM10也与ADHD风险增加有关.
结论:
- 这种MR分析提供了强有力的证据,证明特定空气污染物在某些精神疾病发展中的因果作用.
- 调查结果强调了空气污染减少战略对公共卫生的重要性,以减轻精神疾病的负担.
相关概念视频
Human Genetics
540
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
540
Theoretical Approaches to Psychological Disorder
117
The development of psychological disorders, which are characterized by deviant, maladaptive, and personally distressing behaviors, has been explored through several theoretical approaches.
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
117
Attention-Deficit/Hyperactivity Disorder
47
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
47
Confounding in Epidemiological Studies
148
Confounding in statistical epidemiology represents a pivotal challenge, referring to the distortion in the perceived relationship between an exposure and an outcome due to the presence of a third variable, known as a confounder. This variable is associated with both the exposure and the outcome but is not a direct link in their causal chain. Its presence can lead to erroneous interpretations of the exposure's effect, either exaggerating or underestimating the true association. This...
148
Diagnostic and Statistical Manual of Mental Disorders (DSM)
48
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
48
Stress and Mental Health
83
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
83


