癌症老年人报告的症状严重程度及其对生存预后的影响
1Department of Palliative Medicine, Tan Tock Seng Hospital, Singapore.; Department of Geriatric Medicine, Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore.; Palliative Care Centre for Excellence in Research and Education, Singapore.
Journal of geriatric oncology
|September 27, 2024
概括
患有癌症的老年人报告症状较少,影响生存预后. 然而,高级癌症预后模型 (PRO-MAC) 在所有年龄组中仍然有效.
科学领域:
- 老年瘤学 老年瘤学
- 抚慰性医学是一种缓解性医学.
- 癌症预后 癌症预后
背景情况:
- 症状负担是癌症生存预后的关键.
- 与年轻患者相比,老年人可能会低于报告症状严重程度.
- 年龄对症状报告和预后的影响需要进一步研究.
研究的目的:
- 为了研究年龄如何影响晚期癌症患者的症状严重程度.
- 为了确定与年龄相关的症状报告的预后影响.
- 评估不同年龄组的晚期癌症预后模型 (PRO-MAC) 的有效性.
主要方法:
- 在四个年龄组 (<65,65-74,75-84,≥85) 中比较症状严重程度 (ESAS-r) 和PRO-MAC模型意义.
- 使用多变量Cox比例危险回归和日志等级测试.
- 包括840名患有无法治愈的癌症的患者,由息医学审查.
主要成果:
- 老年人报告症状得分明显较低 (疼痛,疲劳,焦虑,幸福感,ESAS-r总结得分).
- 较高比例的老年人报告没有症状.
- 只有在年轻人群中,ESAS-r总结得分是显著的预后因素;PRO-MAC在所有年龄段仍然适用.
结论:
- 老年癌症患者的症状负担降低可能会影响仅基于症状的生存预后.
- 多维PRO-MAC模型对晚期癌症的老年患者的预后有效.
- 对于更好地捕捉老年人症状严重程度的工具,需要进一步的研究,以改善预后.
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