一项系统性审查和元分析,调查更年期前后慢性炎症和肥胖的差异
Laura E Pernoud1, Paul A Gardiner2, Sean D Fraser1
1School of Health, University of the Sunshine Coast, 90 Sippy Downs Drive, Sippy Downs, Queensland 4556, Australia; Sunshine Coast Health Institute, 6 Doherty Street, Birtinya, Queensland 4572, Australia.
Maturitas
|September 27, 2024
概括
更年期与增加的脂肪和更高水平的adipokines如莱普和adiponectin有关. 需要进一步的研究来证实这些发现,并为有关更年期健康的临床决策提供信息.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 炎症研究 炎症研究
背景情况:
- 更年期是一个重要的生理过渡,标志着荷尔蒙变化.
- 这种过渡与对慢性疾病的易感性增加有关.
- 慢性炎症和脂肪的变化可能会导致这种疾病风险增加.
研究的目的:
- 为了研究前更年期和更年期后妇女之间的炎症和身体脂肪的差异.
- 对更年期状态与关键炎症生物标志物和肥胖指数之间的关联进行元分析.
主要方法:
- 在三个数据库中进行系统的文献搜索.
- 对炎症生物标志物 (莱普丁,阿迪波涅克丁,IL-6,TNF-α,CRP) 和脂肪指数 (脂肪质量,腰围,WHR,BMI) 的元分析.
- 使用NIH工具进行质量评估,GRADE评估的证据确定性.
主要成果:
- 绝经后的妇女表现出显著更高水平的阿迪波涅丁和莱普丁.
- 在绝经后的妇女中观察到瘤亡因子-α增加的趋势.
- 绝经后的女性表现出明显更大的腰围,腰比和体重指数.
结论:
- 与绝经前妇女相比,绝经后妇女的阿迪波金水平升高,脂肪性增加.
- 目前的证据的确定性很低,需要进一步调查.
- 建议进行前性队列研究,以跟踪更年期过渡期间的炎症变化.
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