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在慢性失眠患者的口语流利任务中皮层激活和功能连接:多道NIRS研究

Qi Zhou¹, Chang Li¹, Jia Yu¹

¹Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, 315201, Zhejiang, China; Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, 315201, Zhejiang, China.

Journal of psychiatric research

|September 27, 2024

概括

与健康人群相比,慢性失眠患者在口语流利任务期间,在前额叶皮质中显示出大脑活动和功能连接的减少.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
医疗成像医学成像

背景情况:

慢性失眠与认知功能障碍有关.
大脑的功能连接对于认知过程至关重要.
关于慢性失眠中大脑活动模式的研究有限.

研究的目的:

为了研究慢性失眠患者和健康对照者之间大脑活动和功能连接的差异.
使用口头流利任务 (VFT) 来评估执行功能.
探索失眠中的认知缺陷的神经基础.

主要方法:

招募了84名患有慢性失眠的患者和81名健康对照 (HCs).
在VFT期间使用功能近红外光谱学 (fNIRS) 测量氧血球蛋白 (Oxy-Hb) 度.
分析皮层激活和功能连接模式.

主要成果:

两组之间的VFT表现没有显著差异.
与HC相比,慢性失眠患者表现出前额叶皮层激活 (oxy-Hb) 的降低 (p < 0.05).
在失眠患者中观察到较低的平均通道对通道连接强度 (p < 0.001).

结论:

神经学证据支持慢性失眠中执行功能的变化动态.
失眠患者的脑部活动较弱,与任务相关的功能连接性降低.
研究结果强调了慢性失眠对前额叶皮层功能的影响.

关键词:

慢性失眠症是什么慢性失眠症认知功能障碍认知功能障碍功能性近红外光谱学近红外光谱学氧化血球蛋白是氧化血球蛋白中的一种.语言流性的任务任务

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